MAPPING OF ALDOSE REDUCTASE GENE-SEQUENCES TO HUMAN CHROMOSOME-1, CHROMOSOME-3, CHROMOSOME-7, CHROMOSOME-9, CHROMOSOME-11 AND CHROMOSOME-13

被引：12

作者：

BATEMAN, JB

KOJIS, T

HEINZMANN, C

KLISAK, I

DIEP, A

CARPER, D

NISHIMURA, C

MOHANDAS, T

SPARKES, RS

机构：

[1] NATL INST HLTH, NATL CHILDRENS MED RES CTR, DEPT PEDIAT PHARMACOL, TOKYO 154, JAPAN

[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT OPHTHALMOL, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF LOS ANGELES, HARBOR MED CTR, DIV MED GENE, TORRANCE, CA 90502 USA

[5] NEI, MECHANISM OCULAR DIS LAB, BETHESDA, MD 20892 USA

来源：

GENOMICS | 1993年 / 17卷 / 03期

关键词：

D O I：

10.1006/geno.1993.1372

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization. By in situ hybridization analysis, sequences were localized to human chromosomes 1q32-q42, 3p12, 7q31- q35, 9q22, 11p14-p15, and 13q14-q21. As a putative functional AR gene has been mapped to chromosome 7 and a putative pseudogene to chromosome 3, the sequences on the other seven chromosomes may represent other active genes, non-aldose reductase homologous sequences, or pseudogenes. © 1993 Academic Press. All rights reserved.

引用

页码：560 / 565

页数：6

共 24 条

[1] OSMOREGULATION BY SLOW CHANGES IN ALDOSE REDUCTASE AND RAPID CHANGES IN SORBITOL FLUX [J].