Anti-endothelial cell antibodies in sera from patients with inflammatory bowel disease

被引:0
|
作者
Aldebert, D
Notteghem, B
Reumaux, D
Lassalle, P
Lion, G
Desreumaux, P
Duthilleul, P
Colombel, JF
机构
[1] CHU LILLE,HOP CLAUDE HURIEZ,CLIN MALAD APPAREIL DIGEST & NUTR,F-59037 LILLE,FRANCE
[2] CTR HOSP VALENCIENNES,SERV HEMATOL IMMUNOL CYTOGENET,VALENCIENNES,FRANCE
[3] INST PASTEUR,INSERM,U416,F-59019 LILLE,FRANCE
来源
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE | 1995年 / 19卷 / 11期
关键词
anti-endothelial cell antibodies; Vasculitis; Crohn's disease; ulcerative colitis;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
IgG anti-endothelial cell antibodies (AECA) have been described in sera from patients with vasculitis and other immune disorders such as systemic lupus erythematosus. Presence of AECA may be relevant to the hypothesis that Crohn's disease (CD) is a form of intestinal vasculitis. The aim of this study was to search for IgG AECA among 141 patients with CD, 94 patients with ulcerative colitis (UC) and 71 healthy blood donors and to assess the relationship between AECA and demographic or disease data. The cut-off point was defined from the mean OD values + 2 SD obtained from healthy blood donors. Seventeen percent of sera from patients with CD were positive for IgG AECA, whereas 24.5 % of sera from patients with UC were positive. Among disease data, only a significant relationship between presence of IgG AECA and CD activity was noticed. These results might reinforce the hypothesis that intestinal vascular injury may be an important event in CD. However, defection of AECA in an almost similar percentage of patients with UC is more suggestive of an immune response to hidden endothelial self-antigen exposed after endothelial cell damage or a further marker of disturbed immunoregulation in inflammatory bowel disease.
引用
收藏
页码:867 / 870
页数:4
相关论文
共 50 条
  • [21] Anti-endothelial cell antibodies in patients with retinal vasculitis.
    Manganelli, C
    Locarno, CM
    Turco, S
    DAmico, G
    Manna, R
    Scullica, L
    VISION RESEARCH, 1996, 36 : 1138 - 1138
  • [22] Anti-endothelial cell antibodies in juvenile dermatomyositis
    Karasawa, Rie
    Tamaki, Mayumi
    Sato, Toshiko
    Tanaka, Megumi
    Yudoh, Kazuo
    Jarvis, James
    ARTHRITIS & RHEUMATOLOGY, 2017, 69 : 26 - 27
  • [23] Anti-endothelial cell antibodies in Takayasu arteritis
    Eichhorn, J
    Sima, D
    Thiele, B
    Lindschau, C
    Turowski, A
    Schmidt, H
    Schneider, W
    Haller, H
    Luft, FC
    CIRCULATION, 1996, 94 (10) : 2396 - 2401
  • [24] Natural anti-endothelial cell antibodies (AECA)
    Ronda, N
    Leonardi, S
    Orlandini, G
    Gatti, R
    Bellosta, S
    Bernini, F
    Borghetti, A
    JOURNAL OF AUTOIMMUNITY, 1999, 13 (01) : 121 - 127
  • [25] Anti-endothelial cell antibodies in systemic sclerosis
    Mihai, C.
    Tervaert, J. W. C.
    ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (02) : 319 - 324
  • [26] Pathogenicity of anti-endothelial cell antibodies (AECA)
    Meroni, PL
    Raschi, E
    Testoni, C
    Sabbatini, A
    Panzeri, P
    Cecchini, G
    Borghi, MO
    AUTOANTIGENS AND AUTOANTIBODIES: DIAGNOSTIC TOOLS AND CLUES TO UNDERSTANDING AUTOIMMUNITY, 2000, 1 : 275 - 282
  • [27] Anti-endothelial cell antibodies as disease activity marker in MCTD.
    Mendonca, LLF
    Yoshinari, NH
    Bonoldi, VN
    Khamashta, MA
    Hughes, GRV
    Mariano, M
    Cossermelli, W
    ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 1017 - 1017
  • [28] Functional heterogeneity of anti-endothelial cell antibodies
    Bordron, A
    Révélen, R
    D'Arbonneau, F
    Dueymes, M
    Renaudineau, Y
    Jamin, C
    Youinou, P
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2001, 124 (03): : 492 - 501
  • [29] Anti-endothelial cell antibodies in systemic sclerosis
    Renaudineau, Y
    Revelen, R
    Levy, Y
    Salojin, K
    Gilburg, B
    Shoenfeld, Y
    Youinou, P
    CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1999, 6 (02) : 156 - 160
  • [30] Induction of endothelial cell apoptosis by IgG antibodies from SLE patients with nephropathy - A potential role for anti-endothelial cell antibodies
    Van Paassen, Pieter
    Duijvestijn, A.
    Debrus-Palmans, L.
    Damoiseaux, J.
    Vroomen, M.
    Tervaert, J. W. Cohen
    AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS, 2007, 1108 : 147 - 156