IMMUNODEFICIENT MICE XENOGRAFTED WITH HUMAN LYMPHOID-CELLS - NEW MODELS FOR INVIVO STUDIES OF HUMAN IMMUNOBIOLOGY AND INFECTIOUS-DISEASES

被引：55

作者：

MOSIER, DE

机构：

[1] Division of Immunology, Medical Biology Institute, La Jolla, 92037, California

来源：

JOURNAL OF CLINICAL IMMUNOLOGY | 1990年 / 10卷 / 04期

关键词：

Epstein-Barr virus (EBV) lymphomagenesis; human immunodeficiency virus (HIV) infection; human xenografts; Severe combined immune deficient (SCID) mice;

D O I：

10.1007/BF00918650

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review article deals with the transfer of human lymphoid or hematopoietic tissues to severely immunodeficient mice to create new small animal models for the study of human biology and disease. The degree of functional reconstitution in the three current models is discussed. SCID mice with human grafts have been infected with human immunodeficiency virus (HIV) to generate a small animal model for AIDS research. Epstein-Barr virus (EBV)-related lymphoproliferative disorders can also be modeled by the transfer of adult peripheral blood mononuclear cells to SCID mice. © 1990 Plenum Publishing Corporation.

引用

页码：185 / 191

页数：7

共 17 条

[1]

ANDRIOLE GL, 1985, J IMMUNOL, V135, P2911

[2]

BIRX DL, 1986, NEW ENGL J MED, V14, P8711

[3] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE [J].