ERPS IN SCHIZOPHRENIA - EFFECTS OF ANTIPSYCHOTIC MEDICATION

被引：190

作者：

FORD, JM ^{[1
]}

WHITE, PM ^{[1
]}

CSERNANSKY, JG ^{[1
]}

FAUSTMAN, WO ^{[1
]}

ROTH, WT ^{[1
]}

PFEFFERBAUM, A ^{[1
]}

机构：

[1] STANFORD UNIV,SCH MED,DEPT PSYCHIAT,STANFORD,CA 94305

来源：

BIOLOGICAL PSYCHIATRY | 1994年 / 36卷 / 03期

关键词：

ERPS; SCHIZOPHRENIA; ANTIPSYCHOTIC MEDICATION; P3;

D O I：

10.1016/0006-3223(94)91221-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Thirty unmedicated schizophrenics were compared to 29 age-matched controls on auditory and visual event-related brain potential (ERP) paradigms. Twenty-one of these patients were tested again after 1 week on placebo and after 4 weeks on antipsychotic medication. Before treatment, N1, N2, and P3 components of the auditory ERP were smaller in the schizophrenics than in the controls. Although visual N2 was smaller in schizophrenics, visual P3 was not. In spite of significant clinical improvement with antipsychotic treatment, amplitudes of auditory and visual N1, N2, and P3 were not significantly changed. Higher blood levels of antipsychotic medication were related to reductions in auditory P3 latency, however. In addition, higher levels of cerebrospinal fluid (CSF) MHPG (methoxyhydroxyphenylglycol) were associated with larger auditory N1s and larger auditory and visual P3s, suggesting an influence of arousal an these components in schizophrenics. In spite of this influence, reduction of the auditory P3 in schizophrenia is an enduring trait of the disease, which is nor affected by antipsychotic medication or clinical improvement.

引用

页码：153 / 170

页数：18

共 66 条

[1] BRAIN INDICATORS OF ALTERED ATTENTION AND INFORMATION-PROCESSING IN SCHIZOPHRENIC-PATIENTS [J].