RETROVIRAL INTERLEUKIN-4 GENE-TRANSFER INTO AN INTERLEUKIN-4-DEPENDENT CELL-LINE RESULTS IN AUTOCRINE GROWTH BUT NOT IN TUMORIGENICITY

被引：29

作者：

BLANKENSTEIN, T ^{[1
]}

LI, WQ ^{[1
]}

MULLER, W ^{[1
]}

DIAMANTSTEIN, T ^{[1
]}

机构：

[1] UNIV COLOGNE,INST GENET,W-5000 COLOGNE 41,GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 04期

关键词：

D O I：

10.1002/eji.1830200433

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A retroviral vector has been constructed containing the mouse interleukin 4 (IL 4) gene under the transcriptional control of the thymidine kinase promoter. Infection of the IL 4‐dependent T cell line CT4S by the thymidine kinase IL 4 construct resulted in factor‐independent growth. The infected cells grow as a consequence of continous consumption of the endogenously produced IL 4. Clones were established secreting different amounts of IL 4 but none of them was capable of growing in vivo. The lack of correlation between factor‐independent growth and tumorigenicity distinguishes IL 4 from other growth factors and could reflect the recently reported activity of IL 4 to suppress tumor growth in vivo. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim

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页码：935 / 938

页数：4

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