New Anticoagulants for Stroke Prevention in Patients with Non-Valvular Atrial Fibrillation

被引：0

作者：

Hoecht, T. ^{[1
]}

Frick, M. ^{[2
]}

Alber, H. ^{[2
]}

Huber, K. ^{[1
]}

机构：

[1] Wilhelminenspital Stadt Wien, Med Abt Kardiol & Internist Notaufnahme 3, MontleartstraRe 37

[2] Med Univ Innsbruck, Univ Klin Kardiol, Innsbruck, Austria

来源：

JOURNAL FUR KARDIOLOGIE | 2012年 / 19卷 / 3-4期

关键词：

stroke prevention; non-valvular atrial fibrillation; oral anticoagulation; apixaban; dabigatran; rivaroxaban;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For many years vitamin K antagonists have been the "gold -standard" for effective stroke prevention in patients with non-valvular atrial fibrillation, The search for more practicable and similarly effective oral antico, agulants not only fulfilled but also surpassed the. expectations in form of the direct oral antithrombin dabigatran (RE-LY study) as well as in form of the direct oral anti Xa inhibitors rivaroxaban (ROCKET-AF study} and apixaban (AVERROES and ARISTOTLE trials), respectively. The new agents are safe by significantly reducing bleeding complications as compared to vvarfarin, Especially intracerebral bleedings have been significantly reduced. Accordingly, dabigatran and rivaroxaban have been already approved for stroke prevention in patients with non -valvular atrial fibrillation, while apixaban is expected to follow soon. The current review is ought to familiarize the reader with the new oral anticoagulants in Presenting the recent study re suits.

引用

页码：55 / 62

页数：7

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