PHOSPHORUS MEDIATED CYCLIZATION OF A BETA-ARYLAMINOACRYLAMIDE TO A QUINOLINE - A SIMPLE SYNTHESIS OF SK-AND-F-96067

被引：11

作者：

ANDREWS, IP ^{[1
]}

BANNISTER, R ^{[1
]}

ETRIDGE, SK ^{[1
]}

LEWIS, NJ ^{[1
]}

MULLANE, MV ^{[1
]}

WELLS, AS ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,TONBRIDGE TN11 9AN,KENT,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 42期

关键词：

D O I：

10.1016/0040-4039(95)01578-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reversible (H+/K+)ATPase inhibitor SK&F 96067 1 was prepared in two steps from Meldrum's Acid by cyclisation of the acrylamide 4 with Ph(3)P/C2Cl6/Et(3)N. Evidence for the formation of imidoylketene imine 3 was obtained by trapping with phenyl isocyanate. Thermal degradation of an amidine such as 12 also gave SK&F 96067 1.

引用

页码：7743 / 7746

页数：4

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