2,3-DIDEOXY-FURANOSES IN CONVERGENT SYNTHESES OF 2',3'-DIDEOXY NUCLEOSIDES

被引：0

作者：

DUEHOLM, KL ^{[1
]}

PEDERSEN, EB ^{[1
]}

机构：

[1] ODENSE UNIV,DEPT CHEM,CAMPUSVEJ 55,DK-5230 ODENSE,DENMARK

来源：

SYNTHESIS-STUTTGART | 1992年 / 1-2期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Convergent syntheses, in which a synthetic 2,3-dideoxy-furanose intermediate is condensed with a synthetic base with the aim of producing 2'-substituted-, 3'-substituted- or unsubstituted-2',3'-dideoxy nucleosides - potential HIV inhibitors - are reviewed. It is demonstrated that this approach provides a potential for structural variations, including unnatural configurations, otherwise unattainable. Starting from both carbohydrate and noncarbohydrate precursors synthetic routes to the carbohydrate moiety are emphasized and syntheses of related compounds considered.

引用

页码：1 / 22

页数：22

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