THE CHRONIC MYELOCYTIC CELL-LINE K562 CONTAINS A BREAKPOINT IN BCR AND PRODUCES A CHIMERIC BCR/C-ABL TRANSCRIPT

被引：225
作者：
GROSVELD, G
VERWOERD, T
VANAGTHOVEN, T
DEKLEIN, A
RAMACHANDRAN, KL
HEISTERKAMP, N
STAM, K
GROFFEN, J
机构：
[1] BIOGENE RES CORP,CAMBRIDGE,MA 02142
[2] ONCOGENE SCI INC,MOLEC GENET LAB,MINEOLA,NY 11501
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1986年 / 6卷 / 02期
关键词：
D O I：
10.1128/MCB.6.2.607
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：607 / 616
页数：10
相关论文
共 38 条
[11]   AN 8-KILOBASE ABL RNA TRANSCRIPT IN CHRONIC MYELOGENOUS LEUKEMIA [J].
GALE, RP ;
CANAANI, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (18) :5648-5652
[12]   PHILADELPHIA CHROMOSOMAL BREAKPOINTS ARE CLUSTERED WITHIN A LIMITED REGION, BCR, ON CHROMOSOME-22 [J].
GROFFEN, J ;
STEPHENSON, JR ;
HEISTERKAMP, N ;
DEKLEIN, A ;
BARTRAM, CR ;
GROSVELD, G .
CELL, 1984, 36 (01) :93-99
[13]   ISOLATION OF HUMAN ONCOGENE SEQUENCES (V-FES HOMOLOG) FROM A COSMID LIBRARY [J].
GROFFEN, J ;
GROSVELD, F ;
VANDEVEN, W ;
STEPHENSON, JR .
SCIENCE, 1982, 216 (4550) :1136-1138
[14]   C-SIS IS TRANSLOCATED FROM CHROMOSOME 22 TO CHROMOSOME 9 IN CHRONIC MYELOCYTIC-LEUKEMIA [J].
GROFFEN, J ;
HEISTERKAMP, N ;
STEPHENSON, JR ;
VANKESSEL, AG ;
DEKLEIN, A ;
GROSVELD, G ;
BOOTSMA, D .
JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (01) :9-15
[15]   ISOLATION OF BETA-GLOBIN-RELATED GENES FROM A HUMAN COSMID LIBRARY [J].
GROSVELD, FG ;
DAHL, HHM ;
DEBOER, E ;
FLAVELL, RA .
GENE, 1981, 13 (03) :227-237
[16]   A SIMPLE AND VERY EFFICIENT METHOD FOR GENERATING CDNA LIBRARIES [J].
GUBLER, U ;
HOFFMAN, BJ .
GENE, 1983, 25 (2-3) :263-269
[17]   CHROMOSOMAL LOCALIZATION OF HUMAN CELLULAR HOMOLOGS OF 2 VIRAL ONCOGENES [J].
HEISTERKAMP, N ;
GROFFEN, J ;
STEPHENSON, JR ;
SPURR, NK ;
GOODFELLOW, PN ;
SOLOMON, E ;
CARRITT, B ;
BODMER, WF .
NATURE, 1982, 299 (5885) :747-749
[18]  
HEISTERKAMP N, 1983, Journal of Molecular and Applied Genetics, V2, P57
[19]   LOCALIZATION OF THE C-ABL ONCOGENE ADJACENT TO A TRANSLOCATION BREAK POINT IN CHRONIC MYELOCYTIC-LEUKEMIA [J].
HEISTERKAMP, N ;
STEPHENSON, JR ;
GROFFEN, J ;
HANSEN, PF ;
DEKLEIN, A ;
BARTRAM, CR ;
GROSVELD, G .
NATURE, 1983, 306 (5940) :239-242
[20]   STRUCTURAL ORGANIZATION OF THE BCR GENE AND ITS ROLE IN THE PH' TRANSLOCATION [J].
HEISTERKAMP, N ;
STAM, K ;
GROFFEN, J ;
DEKLEIN, A ;
GROSVELD, G .
NATURE, 1985, 315 (6022) :758-761
1234