IMMOBILIZATION STRESS INDUCES INTERLEUKIN-1-BETA MESSENGER-RNA IN THE RAT HYPOTHALAMUS

被引：256
作者：
MINAMI, M
KURAISHI, Y
YAMAGUCHI, T
NAKAI, S
HIRAI, Y
SATOH, M
机构：
[1] KYOTO UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,KYOTO 606,JAPAN
[2] OTSUKA PHARMACEUT CO LTD,INST CELLULAR TECHNOL,TOKUSHIMA,JAPAN
来源：
NEUROSCIENCE LETTERS | 1991年 / 123卷 / 02期
关键词：
INTERLEUKING-1-BETA; IMMOBILIZATION STRESS; RAT; HYPOTHALAMUS; BIOSYNTHESIS; MESSENGER RNA;
D O I：
10.1016/0304-3940(91)90944-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immobilization stress induced interleukin-1-beta (IL-1-beta) mRNA in the rat hypothalamus. IL-1-beta mRNA was induced at 30 min after the start of immobilization, reached a maximum at 60 min and then was still detected with a decreased level at 120 min. However, 240 min after the start of the immobilization, IL-1-beta mRNA became hardly detectable despite the continuance of immobilization. Distinct expression of IL-1-beta mRNA was not detected in any other brain region examined at 30 and 60 min after the start of immobilization. These results demonstrate that the immobilization stress induces the expression of IL-1-beta mRNA solely in the hypothalamus and suggest that IL-1-beta is involved in the response to stress there.
引用
收藏
页码：254 / 256
页数：3
相关论文
共 13 条
[1]   CORTICOTROPIN-RELEASING FACTOR PRODUCING NEURONS IN THE RAT ACTIVATED BY INTERLEUKIN-1 [J].
BERKENBOSCH, F ;
VANOERS, J ;
DELREY, A ;
TILDERS, F ;
BESEDOVSKY, H .
SCIENCE, 1987, 238 (4826) :524-526
[2]   INTERLEUKIN-1 IMMUNOREACTIVE INNERVATION OF THE HUMAN HYPOTHALAMUS [J].
BREDER, CD ;
DINARELLO, CA ;
SAPER, CB .
SCIENCE, 1988, 240 (4850) :321-324
[3]   GENOMIC SEQUENCE FOR HUMAN PROINTERLEUKIN-1-BETA - POSSIBLE EVOLUTION FROM A REVERSE TRANSCRIBED PROINTERLEUKIN-1-ALPHA GENE [J].
CLARK, BD ;
COLLINS, KL ;
GANDY, MS ;
WEBB, AC ;
AURON, PE .
NUCLEIC ACIDS RESEARCH, 1986, 14 (20) :7897-7914
[4]   INTERLEUKIN-1 [J].
DINARELLO, CA .
REVIEWS OF INFECTIOUS DISEASES, 1984, 6 (01) :51-95
[5]  
FARRAR WL, 1987, J IMMUNOL, V139, P459
[6]   ADRENOCORTICOTROPIN RELEASE INDUCED BY INTRACEREBROVENTRICULAR INJECTION OF RECOMBINANT HUMAN INTERLEUKIN-1 IN RATS - POSSIBLE INVOLVEMENT OF PROSTAGLANDIN [J].
KATSUURA, G ;
GOTTSCHALL, PE ;
DAHL, RR ;
ARIMURA, A .
ENDOCRINOLOGY, 1988, 122 (05) :1773-1779
[7]   IDENTIFICATION OF A HIGH-AFFINITY RECEPTOR FOR INTERLEUKIN-1-BETA IN RAT-BRAIN [J].
KATSUURA, G ;
GOTTSCHALL, PE ;
ARIMURA, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 156 (01) :61-67
[8]   ADRENAL AND URINARY CATECHOLAMINES IN RATS DURING ADAPTATION TO REPEATED IMMOBILIZATION STRESS [J].
KVETNANSKY, R ;
MIKULAJ, L .
ENDOCRINOLOGY, 1970, 87 (04) :738-+
[9]   IMMUNOREACTIVE INTERLEUKIN-1-BETA LOCALIZATION IN THE RAT FOREBRAIN [J].
LECHAN, RM ;
TONI, R ;
CLARK, BD ;
CANNON, JG ;
SHAW, AR ;
DINARELLO, CA ;
REICHLIN, S .
BRAIN RESEARCH, 1990, 514 (01) :135-140
[10]  
MACDONALD RJ, 1987, METHOD ENZYMOL, V152, P219
12