INVIVO EVIDENCE THAT HUMAN ATRIAL NATRIURETIC FACTOR-(99-126) (HANF) STIMULATES PARASYMPATHETIC ACTIVITY IN MAN

被引：12
作者：
ZEUZEM, S
OLBRICH, HG
HAAK, T
JUNGMANN, E
机构：
[1] Center of Internal Medicine, University Hospital, Johann Wolfgang Goethe-University, Frankfurt am Main
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 39卷 / 01期
关键词：
Atrial natriuretic factor-(99-126) (hANF); Heart rate; Parasympathetic activity;
D O I：
10.1007/BF02657063
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In a double-blind study 8 healthy male subjects received 100 μg human atrial natriuretic factor-(99-126) (hANF) and NaC10.9% in random order on different days. Following hANF injection a significant increase in cardiac beat-to-beat variation was observed (4.65% vs 5.95%). This shows that in vivo human atrial natriuretic factor stimulates cardiac parasympathetic activity in man. © 1990 Springer-Verlag.
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页码：77 / 79
页数：3
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