Nonalpine Thyroid Angiosarcoma in a Patient with Hashimoto Thyroiditis

被引:14
作者
Innaro, Nadia [1 ]
Succurro, Elena [2 ]
Tomaino, Giuseppe [1 ]
Arturi, Franco [2 ]
机构
[1] Policlin Mater Domini Catanzaro, Dept Surg, I-88100 Catanzaro, Italy
[2] Magna Graecia Univ Catanzaro, Catanzaro Policlin Mater Domini, Dept Med & Surg Sci, Campus Univ,Viale Europa, I-88100 Catanzaro, Italy
关键词
D O I
10.1155/2013/901246
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Thyroid angiosarcoma is an uncommon thyroid carcinoma and its incidence is the highest in the European Alpine regions. Thyroid angiosarcoma is also a very aggressive tumor that can rapidly spread to the cervical lymph nodes, lungs, and brain or can metastasize to the duodenum, small boewl, and large bowel. Although it is histologically well defined, clear-cut separation between the angiosarcoma and anaplastic thyroid carcinoma is difficult. A 49-year-old Caucasian female patient, born and resident in Southern Italy (Calabria), in an iodine-sufficient area, was admitted to the Surgery Department because she presented with a painless mass in the anterior region of neck enlarged rapidly in the last three months. After total thyroidectomy and right cervical lymphadenectomy, postoperative histological examination revealed the presence of a thyroid angiosarcoma with positive staining for CD31 and for both Factor VIII-related antigen and Vimentin and only partially positive for staining pancytokeratin and presence of metastasis in cervical, supraclavicular, mediastinal and paratracheal lymph nodes. The patient started adjuvant chemotherapy and she was treated for 6 cycles with Doxorubicin, Dacarbazine, Ifosfamide, and Mesna (MAID). After 22 months from surgery, the patient is still alive without both local and systemic recurrence of the disease.
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相关论文
共 22 条
[1]  
Astl J, 2000, NEUROENDOCRINOL LETT, V21, P213
[2]   Severe intestinal bleeding caused by intestinal metastases of a primary angiosarcoma of the thyroid gland [J].
Bandorski, D ;
Arps, H ;
Jaspersen, D ;
Diehl, KL .
ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2002, 40 (09) :811-814
[3]  
CHAN YF, 1986, CANCER, V57, P2381, DOI 10.1002/1097-0142(19860615)57:12<2381::AID-CNCR2820571224>3.0.CO
[4]  
2-Q
[5]  
ECKERT F, 1986, VIRCHOWS ARCH A, V410, P203
[6]   KERATIN-POSITIVE EPITHELIOID ANGIOSARCOMA OF THYROID - A REPORT OF 4 CASES [J].
EUSEBI, V ;
CARCANGIU, ML ;
DINA, R ;
ROSAI, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1990, 14 (08) :737-747
[7]  
Goh Seng Geok Nicholas, 2003, Arch Pathol Lab Med, V127, pE70
[8]   Non-Alpine thyroid angiosarcoma [J].
Gouveia, Pedro ;
Silva, Catarina ;
Magalhaes, Fatima ;
Santos, Claudia ;
Guerreiro, Emanuel ;
Santos, Filipe ;
Gomes, Teixeira .
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2013, 4 (05) :524-527
[9]   GEOGRAPHIC PATHOLOGY OF THYROID-DISEASES [J].
HEDINGER, C .
PATHOLOGY RESEARCH AND PRACTICE, 1981, 171 (3-4) :285-292
[10]   A case of coexistent angiosarcoma and follicular carcinoma of the thyroid [J].
Kim, NR ;
Ko, YH ;
Sung, CO .
JOURNAL OF KOREAN MEDICAL SCIENCE, 2003, 18 (06) :908-913