EXAFS AND FTIR STUDIES ON THE BINDING OF DEOXYCHOLIC-ACID WITH COPPER AND ZINC IONS

被引：11

作者：

HUANG, WD

HU, TD

PENG, Q

SOLOWAY, RD

WENG, SF

WU, JG

机构：

[1] BEIJING UNIV,DEPT CHEM,BEIJING 100871,PEOPLES R CHINA

[2] ACAD SINICA,INST HIGH ENERGY PHYS,BEIJING 100039,PEOPLES R CHINA

[3] UNIV TEXAS,MED BRANCH,DEPT INTERNAL MED,DIV GASTROENTEROL,GALVESTON,TX 77555

来源：

BIOSPECTROSCOPY | 1995年 / 1卷 / 04期

关键词：

D O I：

10.1002/bspy.350010407

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Deoxycholic acid is an important physiological bile acid. The binding of bile salts with metal ions has received more attention due to its clinical significance. In this study, a series of copper and zinc deoxycholate complexes were synthesized. EXAFS and FTIR spectroscopic techniques were used for characterization. The results indicated that both the carboxyl and hydroxyl groups of deoxycholic acid are binding to the Cu (or Zn) ion to form a new complex. There are six oxygen atoms surrounding the metal ion with the average bond lengths of Cu-O and Zn-O are 1.95 and 2.06 Angstrom respectively. (C) 1995 John Wiley & Sons, Inc.

引用

页码：291 / 296

页数：6

共 9 条

[1]

CAREY MC, 1985, STEROLS BILE ACIDS, P345

[2] A MONOCLINIC PHASE OF THE DEOXYCHOLIC-ACID RUBIDIUM SALT [J].