TOTAL SYNTHESES OF MAKALUVAMINE-A, MAKALUVAMINE-B, MAKALUVAMINE-C AND MAKALUVAMINE-D METABOLITES OF THE FIJIAN SPONGE ZYZZA CF MARSAILIS EXHIBITING INHIBITORY ACTIVITIES AGAINST TOPOISOMERASE- II
Total syntheses of the tetrahydropyrroloquinoline-alkaloids, makaluvamines A, B, C and D (1, 2, 3 and 4) have successfully been carried out starting from the appropriate derivatives (5, 8 and 10).