High throughput screening for new drug discovery

被引：0

作者：

Lin, BB ^{[1
]}

机构：

[1] PANLABA TAIWAN LTD,TAIPEI 112,TAIWAN

来源：

JOURNAL OF FOOD AND DRUG ANALYSIS | 1995年 / 3卷 / 04期

关键词：

high throughput screening (HTS); drug discovery; laboratory information management systems (LIMS); natural products discovery; secondary microbial metabolites; combinatorial chemistry; peptide combinatorial libraries; combinatorial organic synthesis;

D O I：

暂无

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The world pharmaceutical market, which was valued at $247.9 billion in 1994, is forecasted to grow to $342 billion by 1999. High throughput screening(HTS) is attracting attention as a novel methodology for new drug discovery, HTS is expected to expand the scale from one thousand to one hundred thousand times the current level by utilizing robots, laboratory information management systems(LIMS), various sources to screen natural products(plant extracts, secondary microbial metabolites), peptide combinatorial libraries and combinatorial organic synthesis(COS) for new therapeutics, Instrumentation, target selection, source material, sample preparation, primary and secondary assays, isolation, purification and structure elucidation are all important for HTS.

引用

页码：233 / 241

页数：9

共 23 条

[1] WIN 64821, A NEW COMPETITIVE ANTAGONIST TO SUBSTANCE-P, ISOLATED FROM AN ASPERGILLUS SPECIES - STRUCTURE DETERMINATION AND SOLUTION CONFORMATION [J].