NEURITIC PLAQUES IN ALZHEIMER-DISEASE ORIGINATE FROM NEUROFIBRILLARY TANGLES

被引：26

作者：

PERRY, G

机构：

[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901

来源：

MEDICAL HYPOTHESES | 1993年 / 40卷 / 04期

关键词：

D O I：

10.1016/0306-9877(93)90051-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of these two lesions means neuritic plaques are not only dependent on neurofibrillary tangles and neuronal death but also dependent on their concurrence.

引用

页码：257 / 258

页数：2

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