NEURITIC PLAQUES IN ALZHEIMER-DISEASE ORIGINATE FROM NEUROFIBRILLARY TANGLES

被引：26

作者：

PERRY, G

机构：

[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901

来源：

MEDICAL HYPOTHESES | 1993年 / 40卷 / 04期

关键词：

D O I：

10.1016/0306-9877(93)90051-Q

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of these two lesions means neuritic plaques are not only dependent on neurofibrillary tangles and neuronal death but also dependent on their concurrence.

引用

页码：257 / 258

页数：2

共 50 条

[21] Morphological Changes of the Human Purkinje Cells and Deposition of Neuritic Plaques and Neurofibrillary Tangles on the Cerebellar Cortex of Alzheimer's Disease
Mavroudis, Ioannis A.
Fotiou, Dimitrios F.
Adipepe, Luc F.
Manani, Marina G.
Njau, Samuel D.
Psaroulis, Dimitrios
Costa, Vasiliki G.
Baloyannis, Stavros J.
AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2010, 25 (07): : 585 - 591
[22] IMMUNOREACTIVITY PATTERNS IN NEUROFIBRILLARY TANGLES OF THE INFERIOR TEMPORAL CORTEX IN ALZHEIMER-DISEASE
DUONG, TH
GALLAGHER, KA
MOLECULAR AND CHEMICAL NEUROPATHOLOGY, 1994, 22 (02) : 105 - 122
[23] ALDEHYDE-MODIFICATION OF THE NEUROFILAMENT COMPONENT OF NEUROFIBRILLARY TANGLES IN ALZHEIMER-DISEASE
RICHEY, PI
SMITH, MA
MILLER, CA
NAWROT, M
PERRY, G
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1993, 52 (03) : 304 - 304
[24] AMYLOID PROTEIN AND NEUROFIBRILLARY TANGLES COEXIST IN THE SAME NEURON IN ALZHEIMER-DISEASE
GRUNDKEIQBAL, I
IQBAL, K
GEORGE, L
TUNG, YC
KIM, KS
WISNIEWSKI, HM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2853 - 2857
[25] SELECTIVE PREOXIDATION ENHANCES SILVER IMPREGNATION OF NEURITIC PLAQUES AND NEUROFIBRILLARY TANGLES
GOLDEN, GT
REYES, PF
CASAS, AW
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1992, 51 (03) : 334 - 334
[26] Neocortical neuritic plaques or neurofibrillary tangles alone do not signify AD
Nature Clinical Practice Neurology, 2007, 3 (8): : 420 - 420
[27] 18Q-SYNDROME - NEUROFIBRILLARY TANGLES WITHOUT NEURITIC PLAQUES
HALLIDAY, WC
CHUDLEY, AE
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (03) : 308 - 308
[28] Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques
Ginsberg, SD
Crino, PB
Lee, VMY
Eberwine, JH
Trojanowski, JQ
ANNALS OF NEUROLOGY, 1997, 41 (02) : 200 - 209
[29] Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques
Mori, H
NEUROPATHOLOGY, 2000, 20 : S55 - S60
[30] The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer's disease
Armstrong, Richard A.
FOLIA NEUROPATHOLOGICA, 2009, 47 (04) : 289 - 299

← 1 2 3 4 5 →