INTERACTION OF TERTATOLOL AT THE ATYPICAL OR BETA3-ADRENOCEPTOR IN GUINEA-PIG ILEUM

被引：7
作者：
BOND, RA [1 ]
VANHOUTTE, PM [1 ]
机构：
[1] BAYLOR COLL MED,CTR EXPTL THERAPEUT,1 BAYLOR PLAZA,ROOM 802E,HOUSTON,TX 77030
来源：
GENERAL PHARMACOLOGY | 1992年 / 23卷 / 02期
关键词：
D O I：
10.1016/0306-3623(92)90005-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. Experiments were performed to investigate the possible interaction between tertatolol and the "atypical" beta-adrenoceptor present in guinea-pig ileum. 2. In the electrically field stimulated guinea-pig ileum, both isoprenaline and BRL-37344 produce concentration-dependent inhibition of the "twitch" response. 3. Schild regression analysis of the interaction between isoprenaline and tertatolol indicated two sites of action and yielded an apoparent pA2 value for tertatolol of 6.8 at the "atypical" beta-adrenoceptor. 4. BRL-37344 selectively activated the "atypical" beta-adrenoceptor and tertatolol again yielded an apparent pA2 value of 6.7 and 6.8.
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页码：171 / 176
页数：6
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