ISOLATION AND SEQUENCE-ANALYSIS OF THE HUMAN APOLIPOPROTEIN-CIII GENE AND THE INTERGENIC REGION BETWEEN THE APO-AI AND APO-CIII GENES

被引：102
作者：
PROTTER, AA [1 ]
LEVYWILSON, B [1 ]
MILLER, J [1 ]
BENCEN, G [1 ]
WHITE, T [1 ]
SEILHAMER, JJ [1 ]
机构：
[1] CALIF BIOTECHNOL INC, 2450 BAYSHORE FRONTAGE RD, Mountain View, CA 94043 USA
来源：
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY | 1984年 / 3卷 / 06期
关键词：
D O I：
10.1089/dna.1.1984.3.449
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The gene for human apolipoprotein CIII, a major component of the triglyceride-rich lipoproteins, was isolated and characterized. Determination of the complete DNA sequence of this gene revealed that the coding sequence is interrupted by 3 introns, which occur in the 5'' noncoding region, in the region encoding the signal sequence and in the region coding for the mature plasma protein, respectively. An analysis of the structure of the apo CIII gene was made and compared to the gene for apolipoprotein AI. The DNA sequence of the intergenic region lying between the apo AI and the apo CIII genes was also described.
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页码：449 / 456
页数：8
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