SYNTHETIC USES OF STEROIDAL RING B DIENE PROTECTION - 22,23-DIHYDROERGOSTEROL

被引：85

作者：

BARTON, DHR ^{[1
]}

GUNATILAKA, AAL ^{[1
]}

NAKANISHI, T ^{[1
]}

PATIN, H ^{[1
]}

WIDDOWSON, DA ^{[1
]}

WORTH, BR ^{[1
]}

机构：

[1] IMPERIAL COLL SCI & TECHNOL, DEPT CHEM, LONDON SW7 2AZ, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1976年 / 08期

关键词：

D O I：

10.1039/p19760000821

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Protection of the ring B diene system of ergosterol by a 2-step addition of the elements of water across the 5,6-double bond, formation of the 4-phenyl-1,2,4-triazoline-3,5-dione adduct, or formation of the iron tricarbonyl adduct by treatment with p-methoxybenzylideneacetonetricarbonyliron, allowed selective reduction of the 22,23-double bond by catalytic or, as appropriate, ionic hydrogenation. Regeneration of the 5,7-diene system in each case gave a high yield of 22,23-dihydroergosterol.

引用

页码：821 / 826

页数：6

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