Renal Medullary Carcinoma: Case Report of an Aggressive Malignancy with Near-Complete Response to Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Chemotherapy

被引：7

作者：

Amjad, Ali Imran ^{[1
]}

Ali, Hira ^{[2
]}

Appleman, Leonard J. ^{[1
]}

Maranchie, Jodi ^{[3
]}

Jackman, Stephen ^{[3
]}

Parwani, Anil ^{[4
]}

Dhir, Rajiv ^{[4
]}

Roy, Somak ^{[4
]}

Parikh, Rahul A. ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Med, Div Hematol & Oncol, Pittsburgh, PA 15232 USA

[2] Univ Pittsburgh, Med Ctr, Dept Med, Div Gen Internal Med, Pittsburgh, PA 15232 USA

[3] Univ Pittsburgh, Sch Med, Dept Urol, Pittsburgh, PA 15232 USA

[4] Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15232 USA

来源：

CASE REPORTS IN ONCOLOGICAL MEDICINE | 2014年 / 2014卷

关键词：

D O I：

10.1155/2014/615895

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Renal medullary carcinoma (RMC) is a rare but aggressive malignancy affecting young individuals with sickle cell trait. Renal medullary carcinoma commonly presents with advanced or metastatic disease and is associated with a rapidly progressive clinical course and an extremely short overall survival measured in weeks to few months. Due to the rarity of RMC, there is no proven effective therapy and patients are often treated with platinum-based chemotherapy. We report near-complete radiological and pathological response in a patient treated with dose-dense MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) chemotherapy. The patient underwent consolidation nephrectomy and retroperitoneal lymph node dissection and had a 16-month progression-free survival, one of the longest reported in patients with RMC.

引用

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