ANALYSIS OF THE PEPTIDE CONTEST OF THE LOCUST VASOPRESSIN-LIKE IMMUNOREACTIVE (VPLI) NEURONS

被引：13
作者：
BAINES, RA
THOMPSON, KSJ
RAYNE, RC
BACON, JP
机构：
[1] Sussex Centre for Neuroscience, University of Sussex, Brighton
来源：
PEPTIDES | 1995年 / 16卷 / 05期
关键词：
CAMP; INHIBITION; INSECT; LOCUSTA MIGRATORIA; NEUROPEPTIDE;
D O I：
10.1016/0196-9781(95)00038-L
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Isolated cell bodies of the locust vasopressin-like immunoreactive (VPLI) neurons, analyzed by HPLC separation and radioimmune assay, contain three arginine vasopressin-like peptides: a previously identified monomer(F1, Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2) and its antiparallel homodimer (F2), but also the previously unreported parallel homodimer (PDm). VPLI neuron activity significantly reduces the level of cAMP in the CNS. Of the three synthetic peptides, only the monomer (F1, 10(-8) and 10(-6) M) is capable of inhibiting a forskolin-stimulated increase in cAMP in isolated neural membranes. The antiparallel (F2) and parallel dimers (PDm) of this peptide have no effect on this second messenger.
引用
收藏
页码：799 / 807
页数：9
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