REDUNDANT MECHANISMS OF CALCIUM-INDUCED CALCIUM-RELEASE UNDERLYING CALCIUM WAVES DURING FERTILIZATION OF SEA-URCHIN EGGS

被引：289

作者：

GALIONE, A

MCDOUGALL, A

BUSA, WB

WILLMOTT, N

GILLOT, I

WHITAKER, M

机构：

[1] JOHNS HOPKINS UNIV,DEPT BIOL,BALTIMORE,MD 21218

[2] UNIV LONDON UNIV COLL,DEPT PHYSIOL,LONDON WC1E 6BT,ENGLAND

来源：

SCIENCE | 1993年 / 261卷 / 5119期

基金：

英国惠康基金;

关键词：

D O I：

10.1126/science.8392748

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Propagating Ca2+ waves are a characteristic feature of Ca2+-linked signal transduction pathways. Intracellular Ca2+ waves are formed by regenerative stimulation of Ca2+ release from intracellular stores by Ca2+ itself. Mechanisms that rely on either inositol trisphosphate or ryanodine receptor channels have been proposed to account for Ca2+ waves in various cell types. Both channel types contributed to the Ca2+ wave during fertilization of sea urchin eggs. Alternative mechanisms of Ca2+ release imply redundancy but may also allow for modulation and diversity in the generation of Ca2+ waves.

引用

页码：348 / 352

页数：5

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