SYNTHESIS OF TRITIUM LABELED MOMETASONE FUROATE

被引：3

作者：

HESK, D ^{[1
]}

DELDUCA, P ^{[1
]}

KOHARSKI, D ^{[1
]}

MCNAMARA, P ^{[1
]}

MAGATTI, C ^{[1
]}

SALUJA, S ^{[1
]}

THOMAS, L ^{[1
]}

机构：

[1] AMERSHAM INT PLC,LITTLE CHALFONT HP7 9NA,BUCKS,ENGLAND

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 05期

关键词：

D O I：

10.1002/jlcr.2580330510

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

H-3-mometasone furoate was synthesized by a six step procedure. The label was introduced via the reduction and re-oxidation of the 1,2 double bond in the A ring. The remaining 4 steps were accomplished with on overall radiochemical yield of 28%. Analysis by H-3 nmr indicated that most of the label (almost-equal-to 95%) was located in the 2-position and the remainder in the 1-position.

引用

页码：439 / 442

页数：4