A PHARMACOLOGICAL GUIDE TO MEDICINES WHICH INTERFERE WITH THE BIODISTRIBUTION OF RADIOLABELED METAIODOBENZYLGUANIDINE (METAIODOBENZYLGUANIDINE)

被引：188
作者：
SOLANKI, KK
BOMANJI, J
MOYES, J
MATHER, SJ
TRAINER, PJ
BRITTON, KE
机构：
[1] Departments of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield
[2] Departments of Paediatric Oncology, St Bartholomew's Hospital, West Smithfield
[3] Departments of Endocrinology, St Bartholomew's Hospital, West Smithfield
来源：
NUCLEAR MEDICINE COMMUNICATIONS | 1992年 / 13卷 / 07期
关键词：
D O I：
10.1097/00006231-199207000-00006
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Radiolabelled meta-iodobenzylguanidine (MIBG) is widely used in the diagnosis, follow-up and treatment of patients with tumours of neural crest origin. Some commonly prescribed and readily available over-the-counter medicines interfere with the uptake and biodistribution of this radiopharmaceutical. This may lead to poor concentration of radiolabelled MIBG within the target organs and tissues. The clinical implications are a potentially inaccurate assessment of tumour burden during diagnostic studies and a suboptimal radiation dose when MIBG is employed for targetted radiotherapy. In order to avoid false negative results a comprehensive list of prescribed and over-the-counter medicines that have the potential to inhibit uptake of MIBG has been compiled. It is hoped that this will help nuclear medicine physicians to avoid this pitfall.
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页码：513 / 521
页数：9
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