FORMULATION AND EVALUATION OF METFORMIN IMMIDIATE RELEASE TABLET

Formulate immediate release tablets of metformin to achieve rapid dissolution, absorption and further improving the bioavailability of the drug. Immediate release tablets and Films of Metformin were designed with a view to enhance the patient compliance and provide a quick onset of action. Metformin Immediate release Tablets were prepared by direct compression method using crosspovidone, croscarmellose sodium, sodium starch glycolate and combinations of CP+CCS, and CP + SSG as super disintegrants Formulations F13, F14, 15 and F16 which contained increasing concentrations of combination of CP + CCS have recorded drug release 94.5%, 96.52%, 99.87% and 96.38% respectively, at the end of 25 to 30 min. Formulations F17, F18, F19 and F20 which contained increasing concentrations of combination of CP + SSG have recorded drug release 88.56%, 92.5%, 95.48% and 94.51respectivel, at the end of 30 min.