PREDOMINANCE OF IGG1 SUBCLASS OF ANTI-RO/SSA, BUT NOT ANTI-LA/SSB ANTIBODIES IN PRIMARY SJOGRENS-SYNDROME

被引：15

作者：

MARAN, R

DUEYMES, M

PENNEC, YL

CASBURNBUDD, R

SHOENFELD, Y

YOUINOU, P

机构：

[1] CHAIM SHEBA MED CTR, DEPT MED B, IL-52621 TEL HASHOMER, ISRAEL

[2] CHAIM SHEBA MED CTR, AUTOIMMUNE DIS RES UNIT, IL-52621 TEL HASHOMER, ISRAEL

[3] BREST UNIV, SCH MED, IMMUNOL LAB, BREST, FRANCE

[4] BREST UNIV, SCH MED, DEPT INTERNAL MED, BREST, FRANCE

[5] CAMBRIDGE LIFE SCI PLC, DEPT RES & DEV, ELY, ENGLAND

来源：

JOURNAL OF AUTOIMMUNITY | 1993年 / 6卷 / 03期

关键词：

D O I：

10.1006/jaut.1993.1032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have developed isotype-specific enzyme-linked immunosorbent assays to assess anti-Ro/SSA and anti-La/SSB IgG subclasses in 31 patients with primary Sjögren's syndrome. The anti-Ro/SSA antibody production was largely but not totally restricted to IgG1, whilst the anti-La/SSB subclass distribution varied from one patient to another. IgG2 and IgG3 anti-La/SSB was more frequent in those patients with extraglandular manifestations. In addition, there were more increases in the IgG2 and IgG4 contribution to anti-La/SSB activity in the 16 DR3-positive patients than in the remaining 10. © 1993 Academic Press. All rights reserved.

引用

页码：379 / 387

页数：9

共 34 条

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