RELAXED SPECIFICITY OF THE OXYTETRACYCLINE POLYKETIDE SYNTHASE FOR AN ACETATE PRIMER IN THE ABSENCE OF A MALONAMYL PRIMER

被引:44
作者
FU, H
EBERTKHOSLA, S
HOPWOOD, DA
KHOSLA, C
机构
[1] STANFORD UNIV,DEPT CHEM ENGN,STANFORD,CA 94305
[2] JOHN INNES CTR,JOHN INNES INST,DEPT GENET,NORWICH NR4 7UH,NORFOLK,ENGLAND
关键词
D O I
10.1021/ja00093a058
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:6443 / 6444
页数:2
相关论文
共 21 条
[1]   CLONING AND HETEROLOGOUS EXPRESSION IN STREPTOMYCES-LIVIDANS OF STREPTOMYCES-RIMOSUS GENES INVOLVED IN OXYTETRACYCLINE BIOSYNTHESIS [J].
BINNIE, C ;
WARREN, M ;
BUTLER, MJ .
JOURNAL OF BACTERIOLOGY, 1989, 171 (02) :887-895
[2]   STUDIES IN RELATION TO BIOSYNTHESIS .28. OXYTETRACYCLINE (TERRAMYCIN) [J].
BIRCH, AJ ;
SNELL, JF ;
THOMSON, PJ .
JOURNAL OF THE CHEMICAL SOCIETY, 1962, (FEB) :425-&
[3]  
FRIEND EJ, 1971, J GEN MICROBIOL, V68, P1187
[4]   ENGINEERED BIOSYNTHESIS OF NOVEL POLYKETIDES - DISSECTION OF THE CATALYTIC SPECIFICITY OF THE ACT KETOREDUCTASE [J].
FU, H ;
EBERTKHOSLA, S ;
HOPWOOD, DA ;
KHOSLA, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (10) :4166-4170
[5]  
FU H, IN PRESS BIOCHEMISTR
[6]  
GATENBECK S, 1961, BIOCHEM BIOPH RES CO, V6, P422
[7]   2-ACETYL-2-DECARBOXAMIDOOXYTETRACYCLINE [J].
HOCHSTEIN, FA ;
VONWITTENAU, MS ;
TANNER, FW ;
MURAI, K .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1960, 82 (22) :5934-5937
[8]  
HOPWOOD DA, 1987, METHOD ENZYMOL, V153, P116
[9]   MOLECULAR-GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY-ACID BIOSYNTHESIS [J].
HOPWOOD, DA .
ANNUAL REVIEW OF GENETICS, 1990, 24 :37-66
[10]  
Hopwood David A., 1993, Current Opinion in Biotechnology, V4, P531, DOI 10.1016/0958-1669(93)90073-6