THE EXPRESSION OF HLA CLASS-I ANTIGEN IN PROSTATE-CANCER IN RELATION TO TUMOR DIFFERENTIATION AND PATIENT SURVIVAL

被引：0

作者：

LEVIN, I ^{[1
]}

KLEIN, T ^{[1
]}

KUPERMAN, O ^{[1
]}

SEGAL, S ^{[1
]}

SHAPIRA, J ^{[1
]}

GAL, R ^{[1
]}

HART, Y ^{[1
]}

KLEIN, B ^{[1
]}

机构：

[1] BEN GURION UNIV NEGEV,SOROKA MED CTR,DEPT UROL,BEER SHEVA,ISRAEL

来源：

CANCER DETECTION AND PREVENTION | 1994年 / 18卷 / 06期

关键词：

HLA; CLASS I ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX (MHC); PROSTATE CANCER; TUMOR DIFFERENTIATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression of HLA class I antigens was studied using the immunoperoxidase technique on 30 patients with prostate cancer and 29 patients with benign prostatic hypertrophy (BPH). Forty-three percent of the tumors stained positive, in contrast to 21% of the BPH. An inverse relationship was noted between class I expression and degree of tumor differentiation: 88% of the well-differentiated tumors (8/9) expressed class I antigen, compared with 33% (3/9) of the moderately differentiated and 16% (2/12) of the poorly differentiated tumors. No significant survival difference was found between those with class I-positive and -negative tumors. However, when both class I expression and degree of differentiation were considered, those with positive tumors at each level of differentiation had better survival than those with negative tumors. These data suggest that HLA class I expression may serve as a finite prognostic factor and may have relevance in future immunotherapy.

引用

页码：443 / 445

页数：3