N-ACETYLASPARTATE AND N-ACETYLASPARTYLGLUTAMATE LEVELS IN ALZHEIMERS-DISEASE POSTMORTEM BRAIN-TISSUE

被引：44

作者：

JAARSMA, D ^{[1
]}

VEENMAVANDERDUIN, L ^{[1
]}

KORF, J ^{[1
]}

机构：

[1] UNIV GRONINGEN, DEPT BIOL PSYCHIAT, PSYCHIAT CLIN, 9700 RB GRONINGEN, NETHERLANDS

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1994年 / 127卷 / 02期

关键词：

AMYGDALA; HIPPOCAMPUS; DEMENTIA; ALZHEIMERS DISEASE; N-ACETYLASPARTATE; N-ACETYLASPARTYLGLUTAMATE; POSTMORTEM BRAIN TISSUE;

D O I：

10.1016/0022-510X(94)90077-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The tissue concentrations of two related amino acid derivatives, N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) were determined in autopsy hippocampus, amygdala, cerebellar cortex and olfactory bulb of Alzheimer's disease patients and age-matched non-demented controls, using reverse-phase HPLC and fluorescence detection after precolumn derivatisation with the fluorophore 2-aminoanthracene. In Alzheimer's disease, NAA and NAAG concentrations were significantly reduced in the hippocampus (by 38 and 24%) and the amygdala (by 28 and 22%), but not in the olfactory bulb and the cerebellar cortex. These results indicate that the concentrations of NAA and NAAG are selectively decreased in brain areas affected by pathology in Alzheimer's disease.

引用

页码：230 / 233

页数：4

共 14 条

[1]

ANTONUO PG, 1985, NEUROLOGY SD, V35, P183

[2] N-ACETYL-L-ASPARTIC ACID - A LITERATURE-REVIEW OF A COMPOUND PROMINENT IN H-1-NMR SPECTROSCOPIC STUDIES OF BRAIN [J].

BIRKEN, DL ;

OLDENDORF, WH .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1989, 13 (01) :23-31

[3]

BLAKELY RD, 1988, INT REV NEUROBIOL, V30, P39

[4]

DAGER SR, 1992, NEUROPSYCHOPHARMACOL, V6, P249

[5] DECREASED BRAIN N-ACETYLASPARTATE IN HUNTINGTONS-DISEASE [J].

DUNLOP, DS ;

MCHALE, DM ;

LAJTHA, A .

BRAIN RESEARCH, 1992, 580 (1-2) :44-48

[6] APPLICATIONS OF MAGNETIC-RESONANCE SPECTROSCOPY AND DIFFUSION-WEIGHTED IMAGING TO THE STUDY OF BRAIN BIOCHEMISTRY AND PATHOLOGY [J].

KAUPPINEN, RA ;

WILLIAMS, SR ;

BUSZA, AL ;

VANBRUGGEN, N .

TRENDS IN NEUROSCIENCES, 1993, 16 (03) :88-95

[7] N-ACETYL-L-ASPARTATE AND OTHER AMINO-ACID METABOLITES IN ALZHEIMERS-DISEASE BRAIN - A PRELIMINARY PROTON NUCLEAR-MAGNETIC-RESONANCE STUDY [J].

KLUNK, WE ;

PANCHALINGAM, K ;

MOOSSY, J ;

MCCLURE, RJ ;

PETTEGREW, JW .

NEUROLOGY, 1992, 42 (08) :1578-1585

[8] N-ACETYL-ASPARTYL-GLUTAMATE - REGIONAL LEVELS IN RAT-BRAIN AND THE EFFECTS OF BRAIN-LESIONS AS DETERMINED BY A NEW HPLC METHOD [J].

KOLLER, KJ ;

ZACZEK, R ;

COYLE, JT .

JOURNAL OF NEUROCHEMISTRY, 1984, 43 (04) :1136-1142

[9] AUTOMATED PRECOLUMN FLUORESCENCE LABELING BY CARBODIIMIDE ACTIVATION OF N-ACETYLASPARTATE AND N-ACETYLASPARTYLGLUTAMATE APPLIED TO AN HPLC BRAIN-TISSUE ANALYSIS [J].

KORF, J ;

VEENMAVANDERDUIN, L ;

VENEMA, K ;

WOLF, JH .

ANALYTICAL BIOCHEMISTRY, 1991, 196 (02) :350-355

[10] N-ACETYL-L-ASPARTIC ACID CONTENT OF HUMAN NEURAL TUMORS AND BOVINE PERIPHERAL NERVOUS TISSUES [J].

NADLER, JV ;

COOPER, JR .

JOURNAL OF NEUROCHEMISTRY, 1972, 19 (02) :313-&

← 1 2 →