SYNTHESIS OF NEVIRAPINE AND ITS MAJOR METABOLITE

被引：19

作者：

GROZINGER, KG

FUCHS, V

HARGRAVE, KD

MAULDIN, S

VITOUS, J

CAMPBELL, S

ADAMS, J

机构：

[1] Boehringer Ingelheim Pharmaceuticals, Inc, Process Chemistry Research, Ridgebury, Connecticut, 06877-0368

[2] Eli Lilly, Indianapolis, Indiana

[3] MyoGenics Inc, Cambridge, Massachusetts, 02139

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 01期

关键词：

D O I：

10.1002/jhet.5570320144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several synthetic methods were developed during the process optimization for the large scale synthesis of nevirapine (1), a non-nucleoside inhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite 11-cyclopropyl-5,11-dihydro-4-hydroxymethyl-6H-[3,2-b:2',3'-e][1,4]diazepin-6-one (2) and the oxidation of 2 to the corresponding aldehyde 3, are described.

引用

页码：259 / 263

页数：5

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