INTERSTITIAL PRESSURE, VOLUME, AND FLOW DURING INFUSION INTO BRAIN-TISSUE

被引：142
作者：
BASSER, PJ
机构：
[1] Mechanical Engineering Section, Biomedical Engineering and Instrumentation Program, National Institutes of Health, Bethesda
来源：
MICROVASCULAR RESEARCH | 1992年 / 44卷 / 02期
关键词：
D O I：
10.1016/0026-2862(92)90077-3
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
A model of infusion-induced swelling in the brain is presented, in which gray and white matter are treated as poroelastic media. The distributions of interstitial pressure, flow, and volume are derived for steady-state and transient infusion protocols. A significant percentage increase in interstitial volume is predicted near the injection site, despite only a modest increase in tissue-averaged fluid content there. The model also can be used to estimate mechanical parameters of brain tissue, such as its hydraulic permeability, shear modulus, and Lamé constant. A solute transport equation that incorporates tissue swelling is also presented. This work suggests that knowing the distribution of swelling induced by infusion is a prerequisite to describing interstitial transport of solutes. © 1992.
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页码：143 / 165
页数：23
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