SWITCH OF CD8 T-CELLS TO NONCYTOLYTIC CD8-CD4- CELLS THAT MAKE T(H)2 CYTOKINES AND HELP B-CELLS

被引：349

作者：

ERARD, F ^{[1
]}

WILD, MT ^{[1
]}

GARCIASANZ, JA ^{[1
]}

LEGROS, G ^{[1
]}

机构：

[1] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND

来源：

SCIENCE | 1993年 / 260卷 / 5115期

关键词：

D O I：

10.1126/science.8511588

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CD8+ T cells are a major defense against viral infections and intracellular parasites. Their production of interferon-gamma (IFN-gamma) and their cytolytic activity are key elements in the immune response to these pathogens. Mature mouse CD8+ T cells that were activated in the presence of interleukin-4 (IL-4) developed into a CD8-CD4- population that was not cytolytic and did not produce IFN-gamma. However, these CD8- cells produced large amounts of IL-4, IL-5, and IL-10 and helped activate resting B cells. Thus, CD8 effector functions are potentially diverse and could be exploited by infectious agents that switch off host protective cytolytic responses.

引用

页码：1802 / 1805

页数：4

共 25 条

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