AN ENANTIOSELECTIVE SYNTHESIS OF THE C(10) TO C(20) FRAGMENT OF FK506

被引：12
|
作者：
MAIER, ME
SCHOFFLING, B
机构：
[1] Fakultät Chemie, Universität Konstanz, D-7750 Konstanz
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 01期
关键词：
D O I：
10.1016/S0040-4039(00)71216-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of the C(10) to C(20) fragment 4 of FK506 from (4S)-4-[(tert-butyldimethylsilyl)-oxymethyl]-4-butanolide (9) is described. A key reaction is the chelation controlled addition of 2-lithio-4-methyl-furan (15b) to aldehyde 8.
引用
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页码：53 / 56
页数：4
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