Crystal structure of 2-isopropyl-4-methoxy-5-methylphenyl 4-methylbenzenesulfonate

被引:1
作者
Laamari, Yassine [1 ]
Auhmani, Aziz [1 ]
Itto, My Youssef Ait [1 ]
Daran, Jean-Claude [2 ]
Auhmani, Abdelwahed [1 ]
Kouili, Mostafa [3 ]
机构
[1] Fac Sci, Dept Chim, Lab Physicochim Mol & Synth Organ, Semlalia BP 2390, Marrakech 40001, Morocco
[2] CNRS, UPR8241, Chim Coordinat Lab, 205 Route Narbonne, F-31077 Toulouse 04, France
[3] Univ Sultan Moulay Slimane, Fac Sci & Tech, Lab Chim Organ & Analyt, BP 523, Beni Mellal 23000, Morocco
关键词
crystal structure; organic synthesis; tosylation of alcohols; drug synthesis;
D O I
10.1107/S2056989018003110
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
The title compound, C18H22O4S, an hemisynthetic product, was obtained by the tosylation reaction of the naturally occurring meroterpene p-methoxythymol. The molecule comprises a tetrasubstitued phenyl ring linked to a toluenesulfonate through one of its O atoms. In the crystal, C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions link the molecules, forming a three-dimensional network.
引用
收藏
页码:419 / +
页数:8
相关论文
共 16 条
[1]   SIR97:: a new tool for crystal structure determination and refinement [J].
Altomare, A ;
Burla, MC ;
Camalli, M ;
Cascarano, GL ;
Giacovazzo, C ;
Guagliardi, A ;
Moliterni, AGG ;
Polidori, G ;
Spagna, R .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1999, 32 :115-119
[2]  
Farrugia L.J., 1997, J APPL CRYSTALLOGR, V30, P565, DOI [10.1107/S0021889897003117, DOI 10.1107/S0021889897003117]
[3]  
Greene T. W., 1999, PROTECTING GROUPS OR
[4]   The Cambridge Structural Database [J].
Groom, Colin R. ;
Bruno, Ian J. ;
Lightfoot, Matthew P. ;
Ward, Suzanna C. .
ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS, 2016, 72 :171-179
[5]   Synthesis and pharmacological profile of 6-methyl-3-isopropyl-2H-1,2-benzothiazin-4(3H)-one 1,1-dioxide derivatives:: non-steroidal anti-inflammatory agents with reduced ulcerogenic effects in the rat [J].
Kacem, Y ;
Kraiem, J ;
Kerkeni, E ;
Bouraoui, A ;
Ben Hassine, B .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 16 (4-5) :221-228
[6]  
Kaleemullah T., 2012, J CHEM PHARM RES, V4, P483
[7]   CHEMICAL SYNTHESIS OF 15-KETOSTEROLS AND THEIR INHIBITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN [J].
KIM, HS ;
OH, SH ;
KIM, DI ;
KIM, IC ;
CHO, KH ;
PARK, YB .
BIOORGANIC & MEDICINAL CHEMISTRY, 1995, 3 (04) :367-374
[8]   Mercury CSD 2.0 -: new features for the visualization and investigation of crystal structures [J].
Macrae, Clare F. ;
Bruno, Ian J. ;
Chisholm, James A. ;
Edgington, Paul R. ;
McCabe, Patrick ;
Pidcock, Elna ;
Rodriguez-Monge, Lucia ;
Taylor, Robin ;
van de Streek, Jacco ;
Wood, Peter A. .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2008, 41 :466-470
[9]   Enzymatic desymmetrization of prochiral 2-substituted-1,3-propanediols: A practical chemoenzymatic synthesis of a key precursor of SCH51048, a broad-spectrum orally active antifungal agent [J].
Morgan, B ;
Dodds, DR ;
Zaks, A ;
Andrews, DR ;
Klesse, R .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (22) :7736-7743
[10]   Synthesis and structural characterization of 5-bromo-2,3-dimethylphenol [J].
Niestroj, AJ ;
Bruhn, C ;
Maier, ME .
JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG, 1998, 340 (02) :175-177