BRAIN CHOLINE IN DEPRESSION - IN-VIVO DETECTION OF POTENTIAL PHARMACODYNAMIC EFFECTS OF ANTIDEPRESSANT THERAPY USING HYDROGEN LOCALIZED SPECTROSCOPY

被引：97

作者：

CHARLES, HC ^{[1
]}

LAZEYRAS, F ^{[1
]}

KRISHNAN, KRR ^{[1
]}

BOYKO, OB ^{[1
]}

PAYNE, M ^{[1
]}

MOORE, D ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT RADIOL,DURHAM,NC 27710

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1994年 / 18卷 / 07期

关键词：

N-ACETYL ASPARTATE; CHOLINE; CHOLINERGIC SYSTEM; MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1016/0278-5846(94)90115-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

引用

页码：1121 / 1127

页数：7

共 13 条

[1] BERGER M, 1985, LANCET, V1, P1385
[2] REGULATION OF HIGH-AFFINITY CHOLINE UPTAKE
BREER, H
KNIPPER, M
[J]. JOURNAL OF NEUROBIOLOGY, 1990, 21 (02): : 269 - 275
[3] NMR CHEMICAL-SHIFT IMAGING IN 3 DIMENSIONS
BROWN, TR
KINCAID, BM
UGURBIL, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (11): : 3523 - 3526
[4] FEIGHNER JP, 1989, PSYCHOPHARMACOL BULL, V25, P219
[5] LOCALIZED HIGH-RESOLUTION PROTON NMR-SPECTROSCOPY USING STIMULATED ECHOES - INITIAL APPLICATIONS TO HUMAN-BRAIN INVIVO
FRAHM, J
BRUHN, H
GYNGELL, ML
MERBOLDT, KD
HANICKE, W
SAUTER, R
[J]. MAGNETIC RESONANCE IN MEDICINE, 1989, 9 (01) : 79 - 93
[6] GERSHON S, 1961, LANCET, V1, P1371
[7] ACETYLCHOLINE AND DEPRESSION
JANOWSKY, DS
ELYOUSEF, MK
DAVIS, JM
[J]. PSYCHOSOMATIC MEDICINE, 1974, 36 (03): : 248 - 257
[8] JANOWSKY DS, 1973, ARCH GEN PSYCHIAT, V28, P542
[9] JANOWSKY DS, 1972, LANCET, V1, P1385
[10] MILLER BL, 1991, MNR BIOMEDICINE, V4, P47

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