THE SYNTHESIS OF PYRANOACRIDINONE INHIBITORS OF PROTEIN-TYROSINE KINASES

被引：23
作者：
GROUNDWATER, PW
SOLOMONS, KRH
机构：
[1] School of Chemistry and Applied Chemistry, University of Wales, College of Cardiff, Cardiff CF1 3TB
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 02期
关键词：
D O I：
10.1039/p19940000173
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
7-Oxo-5,6,7,8-tetrahydroflavone 10 reacts with anthranilonitrile and ethyl anthranilate to give the corresponding enamines. 11 and 13. These enamines undergo base-catalysed cyclization to pyrano[2,3-a] acridin-4-ones, 12 and 14. which undergo oxidation to the fully aromatic systems. 4 and 5. Biological testing of some of these fused heterocyclic systems shows them to have potential in cancer chemotherapy as inhibitors of growth factor-mediated cell proliferation.
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页码：173 / 177
页数：5
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