SYNTHESIS OF THE THYMIDINE BUILDING-BLOCKS FOR A NONHYDROLYZABLE DNA ANALOG

被引：14

作者：

KAWAI, SH ^{[1
]}

WANG, DG ^{[1
]}

JUST, G ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL H3A 2K6,QUEBEC,CANADA

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1992年 / 70卷 / 05期

关键词：

D O I：

10.1139/v92-193

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 3'-deoxy-3'-C-(2''-hydroxyethyl)thymidine derivatives 4 and 13 were efficiently synthesized from either thymidine via a known 3'-radical allylation, or from the branched-chain furanose 5 involving the removal of the 2'-hydroxyl after stereospecific nucleosidation. The 5'-deoxy-5'-thiothymidine 20 was prepared via a regiospecific Mitsunobu coupling, providing the third unit required for the synthesis of sulfide-linked DNA analogues.

引用

收藏

页码：1573 / 1580

页数：8

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