STAPHYLOCOCCAL ENTEROTOXIN-B AS A POTENT SUPPRESSANT OF T-CELL PROLIFERATIVE RESPONSES IN RATS

The staphylococcal toxins are well known as stimulators of powerful T lymphocyte proliferative responses. Staphylococcal enterotoxin B (SEB) was found, in both humans and mice, to preferentially stimulate T cells bearing particular V-beta gene products as part of their functional T cell receptor alpha/beta. In contrast to this reported stimulatory activity we demonstrate here that SEB is a poor stimulant of T lymphocyte proliferative responses in Lewis rats. Moreover, under appropriate conditions, SEB can serve as a powerful suppressant of Lewis rat T lymphocytes, capable of abolishing their antigen-specific or mitogen-stimulated proliferative responses. Suppression of mitogen-induced proliferative responses of rat T cell clones was effective in the presence of syngeneic or allogeneic accessory cells and similar to its stimulatory characteristics, SEB suppressed high proportions of rat T lymphocyte subsets. These data suggest that in certain circumstances SEB can be considered a "supersuppressogen" as well as a "superantigen". Whether SEB will be "superantigen" or "supersuppressogen" is likely to depend on the TcR elements of the lymphocytes as well as on the MHC molecules presenting SEB.