DIRECT CHROMATOGRAPHIC RESOLUTION OF RACEMIC CYCLOHEXYLAMINOGLUTETHIMIDE AND ITS ACETYLATED METABOLITE USING CELLULOSE-BASED CHIRAL STATIONARY PHASE

被引：7

作者：

ABOULENEIN, HY

BAKR, SA

机构：

[1] Drug Development Laboratory, Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211

来源：

CHIRALITY | 1991年 / 3卷 / 03期

关键词：

CHIRAL CHROMATOGRAPHY; CELLULOSE-BASED CHIRAL STATIONARY PHASE; AROMATASE INHIBITOR; CYCLOHEXYLAMINOGLUTETHIMIDE AND METABOLITE; ENANTIOMERIC SEPARATION;

D O I：

10.1002/chir.530030311

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Racemic cyclohexylaminoglutethimide (+/- ChAG) and its acetylated metabolite (+/- AChAG) were resolved by a direct chromatographic method using a Chiracel OD column without derivatization. Maximum resolutions (R) of 4.89 and 0.74 were obtained for the enantiomers of cyclohexylaminoglutethimide and its acetylated metabolite, respectively.

引用

页码：204 / 207

页数：4

共 8 条

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