Efficacy and safety of Citrus sudachi peel in obese adults: A randomized, double-blind, pilot study

被引：5

作者：

Akaike, Masashi ^{[1
]}

Aihara, Ken-ichi ^{[2
]}

Yanagawa, Hiroaki ^{[7
]}

Iwase, Takashi ^{[3
]}

Yoshida, Sumiko ^{[2
]}

Sato, Chiho ^{[7
]}

Saijo, Tomoka ^{[7
]}

Mikasa, Hiroaki ^{[8
]}

Kashiwada, Yoshizaki ^{[4
]}

Takaishi, Yoshihisa ^{[4
]}

Tsuchiya, Koichiro ^{[5
]}

Tamaki, Toshiaki ^{[6
]}

Matsumoto, Toshio ^{[2
]}

Sata, Masataka ^{[3
]}

机构：

[1] Univ Tokushima, Grad Sch Med Sci, Dept Med Educ, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan

[2] Univ Tokushima, Grad Sch Med Sci, Dept Med & Bioregulatroy Sci, Tokushima 7708503, Japan

[3] Univ Tokushima, Grad Sch Med Sci, Dept Cardiovasc Med, Tokushima 7708503, Japan

[4] Univ Tokushima, Grad Sch Med Sci, Dept Nat Med, Tokushima 7708503, Japan

[5] Univ Tokushima, Grad Sch Med Sci, Dept Med Pharmacol, Tokushima, Japan

[6] Univ Tokushima, Grad Sch Med Sci, Dept Pharmacol, Tokushima 7708503, Japan

[7] Tokushima Univ Hosp, Clin Trial Ctr Dev Therapeut, Tokushima 7708503, Japan

[8] Univ Tokushima, Support Ctr Med Educ, Sch Med, Tokushima 7708503, Japan

来源：

FUNCTIONAL FOODS IN HEALTH AND DISEASE | 2014年 / 4卷 / 07期

关键词：

health functional food; anti-obesity; triglyceride;

D O I：

10.31989/ffhd.v4i7.5

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Objective: This study was undertaken to explore the efficacy and safety of Citrus sudachi peel for metabolic risk factors in obese male and female adults. Background: Citrus sudachi Hort. ex Shirai ( Rutaceae), called "sudachi", is a small, round, green citrus fruit that is mainly cultivated in Tokushima Prefecture in Japan. Our group reported that Citrus sudachi peel powder improved glucose tolerance and dyslipidemia in Zucher-fatty rats and reduced hyperglycemia and hypertriglyceridemia in GK diabetic rats. Materials and Methods: We conducted a randomized, double-blind, placebo-controlled trial in 40 participants with abdominal obesity and metabolic risk factors including hypertension, impaired glucose tolerance and elevated triglyceride levels. Participants were randomized to receive either tablets that contained 1.3 g dried Citrus sudachi peel powder or placebo tablets for 12 weeks. The sudachi peel group included 14 males and 5 females with a mean age of 54.5 years, and the placebo group included 18 males and 2 females with a mean age of 51.9 years. Results: Physical status including body weight, waist circumference and blood pressure and laboratory markers including metabolic parameters were not different at any observation point between the two groups. However, among participants with serum triglyceride levels of more than 120 mg/dl, body weight, waist circumference and serum triglyceride levels were significantly decreased at several observation points after the start of treatment in the sudachi peel group but not in the placebo group. No serious adverse events were observed in the sudachi peel group. Conclusions: Citrus sudachi peel has the potential effect to safely improve abdominal obesity and lower serum levels of TG in obese individuals with hypertriglyceridemia. A large-scale randomized, double-blind clinical study targeting subjects with both abdominal obesity and high TG levels is needed to confirm the metabolic effects of Citrus sudachi peel.

引用

页码：276 / 284

页数：9

共 11 条

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