INVITRO METABOLISM OF SPARTEINE BY HUMAN-LIVER - COMPETITIVE-INHIBITION BY DEBRISOQUINE

被引：57
作者：
OTTON, SV [1 ]
INABA, T [1 ]
MAHON, WA [1 ]
KALOW, W [1 ]
机构：
[1] UNIV TORONTO,FAC MED,DEPT PHARMACOL,TORONTO M5S 1A8,ONTARIO,CANADA
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1982年 / 60卷 / 01期
关键词：
D O I：
10.1139/y82-017
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：102 / 105
页数：4
相关论文
共 11 条
[1]   PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE [J].
BERTILSSON, L ;
DENGLER, HJ ;
EICHELBAUM, M ;
SCHULZ, HU .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 17 (02) :153-155
[2]   NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN [J].
BERTILSSON, L ;
EICHELBAUM, M ;
MELLSTROM, B ;
SAWE, J ;
SCHULZ, HU ;
SJOQVIST, F .
LIFE SCIENCES, 1980, 27 (18) :1673-1677
[3]   EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER [J].
DAVIES, DS ;
KAHN, GC ;
MURRAY, S ;
BRODIE, MJ ;
BOOBIS, AR .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1981, 11 (01) :89-91
[4]   DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].
EICHELBAUM, M ;
SPANNBRUCKER, N ;
STEINCKE, B ;
DENGLER, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187
[5]   A FAMILY AND POPULATION STUDY OF THE GENETIC-POLYMORPHISM OF DEBRISOQUINE OXIDATION IN A WHITE BRITISH-POPULATION [J].
EVANS, DAP ;
MAHGOUB, A ;
SLOAN, TP ;
IDLE, JR ;
SMITH, RL .
JOURNAL OF MEDICAL GENETICS, 1980, 17 (02) :102-105
[6]   POLYMORPHISMS OF OXIDATION AT CARBON CENTERS OF DRUGS AND THEIR CLINICAL SIGNIFICANCE [J].
IDLE, JR ;
SMITH, RL .
DRUG METABOLISM REVIEWS, 1979, 9 (02) :301-317
[7]   DEFICIENT METABOLISM OF DEBRISOQUINE AND SPARTEINE [J].
INABA, T ;
OTTON, SV ;
KALOW, W .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 27 (04) :547-549
[8]   POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN [J].
MAHGOUB, A ;
IDLE, JR ;
DRING, LG ;
LANCASTER, R ;
SMITH, RL .
LANCET, 1977, 2 (8038) :584-586
[9]   POLYMORPHISM OF CARBON OXIDATION OF DRUGS AND CLINICAL IMPLICATIONS [J].
SLOAN, TP ;
MAHGOUB, A ;
LANCASTER, R ;
IDLE, JR ;
SMITH, RL .
BRITISH MEDICAL JOURNAL, 1978, 2 (6138) :655-657
[10]  
TUCKER GT, 1977, LANCET, V2, P718
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