Antidotes: Benefits and risks

被引:3
作者
Proudfoot, AT
机构
[1] Scottish Poisons Information Bureau, Royal Infirmary, Edinburgh NHS Trust, Edinburgh, Lauriston Place
关键词
acetylcysteine; naloxone; flumazenil; desferrioxamine; haemodynamics; mechanisms;
D O I
10.1016/0378-4274(95)03519-2
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The ability of naloxone and flumazenil to reverse serious toxicity due to their respective agonists is well known. Their adverse effects are minor and few but flumazenil administration may unmask seizures in poisoning with combinations of benzodiazepines and tricyclic antidepressants. The desferrioxamine challenge test is frequently falsely negative and should be abandoned. In addition to being cytoprotective, N-acetylcysteine has potent vasodilator and positive inotropic actions which may be partly responsible for its beneficial effect in late-presentation paracetamol overdosage with hepatic damage and failure.
引用
收藏
页码:779 / 783
页数:5
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