EFFECTS OF PICROLIV, THE ACTIVE PRINCIPLE OF PICRORHIZA-KURROA, BIOCHEMICAL-CHANGES IN RAT-LIVER POISONED BY AMANITA-PHALLOIDES

被引：0
作者：
DWIVEDI, Y [1 ]
RASTOGI, R [1 ]
GARG, NK [1 ]
DHAWAN, BN [1 ]
机构：
[1] CENT DRUG RES INST, INDIAN COUNCIL MED RES, CTR ADV PHARMACOL RES TRADIT REMEDIES, LUCKNOW 226001, UTTAR PRADESH, INDIA
来源：
ACTA PHARMACOLOGICA SINICA | 1992年 / 13卷 / 03期
关键词：
AMANITA; PICRORHIZA-KURROA; PICROLIV; LIVER; ENZYME TESTS; CYTOCHROME-P-450; LIVER GLYCOGEN;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The efficacy of Picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa, was studied against the Amanita phalloides-induced biochemical changes in rat liver. A phalloides (50 mg . kg-1) caused significant increases in the activities of hepatic 5'-nucleotidase, gamma-glutamyl transpeptidase, acid ribonuclease, and succinate dehydrogenase, but a decrease in glucose-6-phosphatase. The level of cytochrome P-450 in microsomal fraction and content of glycogen in liver showed significant depletions. Picroliv (25 mg . kg-1 . d-1 x 10 d) provided significant restorations of all the biochemical changes poisoned by A phalloides except cytochrome P-450 and glycogen. These results demonstrated the protective effect of Picroliv against A phalloides-induced hepatotoxicity in rats.
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页码：197 / 200
页数：4
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