SYNTHESIS AND REACTIONS OF N-CHLOROMETHYL-1,2,4-TRIAZOLES WITH SULFUR AND OXYGEN NUCLEOPHILES

被引：12

作者：

ELWASSIMY, MTM ^{[1
]}

ABDELRAHMAN, M ^{[1
]}

GHATTAS, ABAG ^{[1
]}

ALLAH, OAAA ^{[1
]}

机构：

[1] FAC SCI SOHAG,DEPT CHEM,SOHAG,EGYPT

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1992年 / 70卷 / 1-2期

关键词：

2-CHLOROMETHYL-1,2,4-TRIAZOLE-3-THIONE; THIOLS; ALKOXIDES;

D O I：

10.1080/10426509208049156

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

2-Chloromethyl-1,2,4-triazole-3-thione derivatives (1 and 2) were synthesized through the hydroxymethyl derivatives, and reacted with alkyl, aryl and heteroaryl thiols to give the corresponding sulfides (3-15). Compounds 1 and 2 were reacted with sodium alkoxides and phenoxide affording the corresponding ethers (19-24). Transformation of C=S to C=O has been achieved by the action of mercuric acetate. Condensation of compounds 1 and 2 with hydrazine, phenylhydrazine and hydroxylamine yielded bicyclic condensation products 27-32. Activity of the newly synthesized compounds against different kinds of fungi has been investigated in vitro.

引用

页码：99 / 108

页数：10

共 13 条

[1] SYNTHESIS OF 2-THIOXO-3-BENZOTHIAZOLINEACETONITRILE AND RELATED PRODUCTS [J].