INDUCTION OF PREMATURE CENTROMERE DIVISION AFFECTING ALL CHROMOSOMES UNDER CULTURE CONDITIONS OF FRAGILE SITE EXPRESSION

被引：6

作者：

FUSTER, C

MIRO, R

BARRIOS, L

EGOZCUE, J

机构：

[1] Departament de Biologia Cellular i Fisiologia, Subunitat de Biologia, Facultat de Medicina, Barcelona

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 58卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90102-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a study of chromosome fragility carried out under folate and thymidine deficiency conditions, we observed a seven- to ninefold increase of the incidence of premature centromere divisions (PCDs) affecting all chromosomes. This early separation of centromeres is clearly a culture effect and distinct from PCD and centromere splitting (CS), which imply a defect in the centromere of one or more chromosomes.

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页码：152 / 154

页数：3

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