HEPARIN-FREE CARDIOPULMONARY BYPASS - 1ST REPORTED USE OF HEPARINOID (ORG 10172) TO PROVIDE ANTICOAGULATION FOR CARDIOPULMONARY BYPASS

被引：64

作者：

DOHERTY, DC

ORTEL, TL

DEBRUIJN, N

GREENBERG, CS

VANTRIGT, P

机构：

[1] DUKE UNIV,MED CTR,DEPT MED,DURHAM,NC 27710

[2] DUKE UNIV,CTR HEART,DEPT SURG,DURHAM,NC 27706

[3] DUKE UNIV,MED CTR,COAGULAT LAB,DURHAM,NC 27710

[4] DUKE UNIV,MED CTR,DEPT SURG,DURHAM,NC 27710

[5] PIEDMONT HOSP,DEPT ANESTHESIOL,DIV CARDIAC ANESTHESIA,ATLANTA,GA 30309

来源：

ANESTHESIOLOGY | 1990年 / 73卷 / 03期

关键词：

Blood; coagulation; Cardiac: cardiopulmonary bypass; Heparin; Org; 10172; antithrombin; anti-factor Xa surgery;

D O I：

10.1097/00000542-199009000-00034

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Org 10172 provided adequate anticoagulation for this patient. An excellent correlation between anti-factor Xa activity and ACT was observed at the doses used for CPB. If high-dose Org 10172 is used, these data suggest that it may be possible to circumvent the measurement of anti-factor Xa activity by using the ACT as an index of this heparinoid's anticoagulant effect. Because postoperative bleeding may be excessive, however, development of a method of reversal of Org 10172 is desirable. Although the optimal ACT, dose, plasma concentration, and means of reversal (e.g., protamine vs. heparinase) remains to be determined, heparinoids provide an alternate means of anticoagulation for CPB in patients unable to receive standard heparin.

引用

页码：562 / 565

页数：4

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