The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

被引：1
|
作者：
Whitsett, Timothy G. [1 ]
Inge, Landon J. [2 ]
Tran, Nhan L. [1 ]
机构：
[1] Translat Genom Res Inst, Canc & Cell Biol Div, Phoenix, AZ USA
[2] St Josephs Hosp, Ctr Thorac Dis & Transplantat, Heart & Lung Inst, Phoenix, AZ USA
来源：
TRANSLATIONAL LUNG CANCER RESEARCH | 2013年 / 2卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Lung squamous cell carcinoma; proteomics; isobaric tags for relative and absolute quantitation (iTRAQ); glutathione s-transferase pi 1 (GSTP1);
D O I：
10.3978/j.issn.2218-6751.2013.10.17
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.
引用
收藏
页码：457 / 460
页数：4
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