Postradiation Histiocytic Sarcoma in the Setting of Muir-Torre Syndrome

被引：3

作者：

Baumgartner, Erin ^{[1
]}

Ullman, David ^{[1
]}

Jones, Jeffrey Adam ^{[1
]}

Fasciano, Danielle ^{[1
]}

Atherton, Daniel S. ^{[1
]}

Pavlidakey, Peter ^{[2
]}

Peker, Deniz ^{[1
]}

机构：

[1] UAB, Dept Pathol, Birmingham, AL 35294 USA

[2] UAB, Dept Dermatol, Birmingham, AL USA

来源：

CASE REPORTS IN PATHOLOGY | 2018年 / 2018卷

关键词：

D O I：

10.1155/2018/5947870

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is an autosomal dominant genetic disorder characterized by a predisposition towards colorectal carcinoma and other extracolonic neoplasms. Histiocytic sarcoma (HS) is a very rare hematologic neoplasm characterized by a malignant proliferation of cells with histiocytic differentiation. We present the case of a 62-year-old male with previous diagnosis of MTS who presented with metastatic colorectal adenocarcinoma, bilateral papillary renal cell carcinoma, and a new squamous cell carcinoma of the scalp, treated with resection and adjuvant radiation therapy. After reconstructive surgery for his scalp resection, the patient developed a persistent nonhealing skin defect. A punch biopsy of this nonhealing skin defect and subsequent immunohistochemistry revealed neoplastic histiocytic cells restricted to the epidermis and underlying dermis. The diagnosis of cutaneous histiocytic sarcoma was then rendered. Histiocytic sarcoma is an exceptionally rare malignancy. Consequently, there is no universally agreed upon management protocol for this malignancy. The patient was admitted to hospice and treated with palliative radiation. This case demonstrates the need for awareness of the risk of secondary malignancies in cancer patients in order to facilitate early surgical intervention and optimal treatment.

引用

页数：4

共 15 条

[1] Syndrome of early onset colon cancers, hematologic malignancies & features of neurofibromatosis in HNPCC families with homozygous mismatch repair gene mutations [J].