COMPARATIVE-EVALUATION OF CLINICAL AND CARDIOHEMODYNAMIC EFFECTS OF CALCIUM-ANTAGONISTS OF DIHYDROPYRIDINE GROUP IN PATIENTS WITH ARTERIAL-HYPERTENSION

Calcium antagonists of the dihydropirydine group - nifedipine, nitrendipine and isradipine were used as monotherapy in 67 patients with mild to moderate hypertension. Overall results of treatment were positive in 68%, 64%, and 62% of patients for nifedipine, nitrendipine, and isradipine, respectively. In mean therapeutic doses nifedipine, nitrendipine and isradipine decreased diastolic blood pressure by 13%, 12%, 13% and total peripheral vascular resistance by 22%, 18%, and 20%, respectively, without producing negative chrono- and inotropic effects. Effects of all three dihydropyridines on parameters of cardiohemodynamics were identical. Nifedipine, nitrendipine and isradipine were shown to be equally effective for treatment of mild and moderate hypertension.