INTRACORONARY ACETYLCHOLINE-INDUCED PROLONGATION OF THE QT INTERVAL AND TORSADE-DE-POINTES IN LONG QT INTERVAL SYNDROME

被引：0
|
作者：
AIZAWA, Y
MATSUBARA, T
HIGUCHI, K
WASHIZUKA, T
TAMURA, Y
UCHIYAMA, H
IGARASHI, Y
SHIBATA, A
机构：
来源：
JAPANESE HEART JOURNAL | 1994年 / 35卷 / 05期
关键词：
LONG QT INTERVAL SYNDROME; QT PROLONGATION; ACETYLCHOLINE; TORSADE-DE-POINTES;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 75-year-old female had syncopal episodes from Torsade des Pointes (TdP). Her electrocardiogram showed a prolonged QT interval which was not associated with electrolyte imbalances or drug therapy. Similar electrocardiographic abnormalities were found in three family members. Electrophysiologic study showed a mildly prolonged effective refractory period of 260-290 msec, but no tachyarrhythmia was induced. Coronary arteriography was normal but intracoronary acetylcholine unexpectedly induced a prolongation of the QT interval and TdP. Direct action of acetylcholine on the ventricular muscle was suggested.
引用
收藏
页码：683 / 688
页数：6
相关论文
共 50 条
  • [31] Utility of QT interval corrected by Rautaharju method to predict drug-induced torsade de pointes
    Othong, Rittirak
    Wattanasansomboon, Suttisak
    Kruutsaha, Thanakorn
    Chesson, Douglas
    Vallibhakara, Sakda Arj-Ong
    Kazzi, Ziad
    CLINICAL TOXICOLOGY, 2019, 57 (04) : 234 - 239
  • [32] "Torsade de pointes" during amiodarone infusion in a cirrhotic woman with a prolonged QT interval
    Di Micoli, A.
    Zambruni, A.
    Bracci, E.
    Benazzi, B.
    Zappoli, P.
    Berzigotti, A.
    Zoli, M.
    Bernardi, A.
    Trevisani, F.
    DIGESTIVE AND LIVER DISEASE, 2009, 41 (07) : 535 - 538
  • [33] Development of cardiac safety translational tools for QT prolongation and torsade de pointes
    Valerio, Luis G., Jr.
    Balakrishnan, Suchitra
    Fiszman, Monica L.
    Kozeli, Devi
    Li, Mike
    Moghaddam, Sarvin
    Sadrieh, Nakissa
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2013, 9 (07) : 801 - 815
  • [34] QT interval abnormalities: risk factors and perioperative management in long QT syndromes and Torsades de Pointes
    Alan David Kaye
    Jacqueline Volpi-Abadie
    J. Michael Bensler
    Adam M. Kaye
    James H. Diaz
    Journal of Anesthesia, 2013, 27 : 575 - 587
  • [35] Aliskiren-Induced QT Interval Prolongation
    Peitz, Gregory J.
    Malesker, Mark A.
    Sojka, S. George
    SOUTHERN MEDICAL JOURNAL, 2009, 102 (04) : 411 - 412
  • [36] QT interval abnormalities: risk factors and perioperative management in long QT syndromes and Torsades de Pointes
    Kaye, Alan David
    Volpi-Abadie, Jacqueline
    Bensler, J. Michael
    Kaye, Adam M.
    Diaz, James H.
    JOURNAL OF ANESTHESIA, 2013, 27 (04) : 575 - 587
  • [37] Antidepressants: Their effects on cardiac channels, QT prolongation and Torsade de Pointes
    Sala, M
    Coppa, F
    Cappucciati, C
    Brambilla, P
    d'Allio, G
    Caverzasi, E
    Barale, F
    De Ferrari, GM
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2006, 7 (03) : 256 - 263
  • [38] Diphenhydramine induced QT prolongation and torsade de pointes: An uncommon effect of a common drug
    Husain, Zehra
    Hussain, Khursheed
    Nair, Rajiv
    Steinman, Russell
    CARDIOLOGY JOURNAL, 2010, 17 (05) : 509 - 511
  • [39] Therapeutic hypothermia-induced QT prolongation and ,,torsade de pointes" ventricular tachycardia
    Tomcsanyi Janos
    Aranyi Peter
    Arabadzisz Hrisula
    ORVOSI HETILAP, 2022, 163 (13) : 523 - 526
  • [40] Efavirenz-associated QT prolongation and Torsade de Pointes arrhythmia
    Castillo, R
    Pedalino, RP
    El-Sherif, N
    Turitto, G
    ANNALS OF PHARMACOTHERAPY, 2002, 36 (06) : 1006 - 1008
12345